Table 1 Demographic variables for the CAVAS, KARE, and HEXA cohorts
| Â | CAVAS | pa | KARE | p | HEXA | p | |||
|---|---|---|---|---|---|---|---|---|---|
Case (n = 95) | Control (n = 2908) | Case (n = 112) | Control (n = 5308) | Case (n = 975) | Control (n = 57,459) | ||||
Sex | |||||||||
 Male | 37 (3.1%) | 1164 (96.9%) | 0.8325 | 39 (1.5%) | 2563 (98.5%) | 0.0048 | 283 (1.4%) | 19,924 (98.6%) |  < 0.0001 |
 Female | 58 (3.2%) | 1744 (96.8%) | 73 (2.6%) | 2745 (97.4%) | 692 (1.8%) | 37,535 (98.2%) | |||
Age (years)b | 57.9 ± 7.8 | 55.4 ± 7.8 | 0.0025 | 53.3 ± 7.9 | 51.5 ± 8.5 | 0.0026 | 55.4 ± 8.4 | 53.8 ± 8.0 |  < 0.0001 |
BMI (kg/m2) | 25.5 ± 3.4 | 24.5 ± 3.0 | 0.0002 | 25.0 ± 3.5 | 24.6 ± 3.0 | 0.1536 | 24.3 ± 3.2 | 23.9 ± 2.9 | 0.0002 |
Smoking statusc | |||||||||
 Non-Smokers | 72 (3.0%) | 2123 (97.0%) | 0.5471 | 71 (2.2%) | 3173 (97.8%) | 0.4397 | 721 (1.7%) | 42,070 (98.3%) | 0.6348 |
 Smokers | 23 (2.8%) | 785 (97.2%) | 41 (1.9%) | 2135 (98.1%) |  | 254 (1.6%) | 15,389 (98.4%) |  | |
Allergy status | |||||||||
 Non-allergy | 74 (2.7%) | 2695 (97.3%) |  < 0.0001 | 86 (1.7%) | 5015 (98.3%) |  < 0.0001 | 727 (1.3%) | 53,642 (98.7%) |  < 0.0001 |
 Allergy | 21 (9.0%) | 213 (91.0%) | 26 (8.2%) | 293 (91.8%) | 248 (6.1%) | 3,817 (93.9%) | |||