Fig. 1

ATAC-seq profiles of chromosome 9 form A549 cells. A TN5 binds to open chromatin, cutting DNA and adding primers to generate a paired-end sequencing library. B A549, ATAC-seq replicates along chromosome 9. Samples were generated using fresh cells (green) and previously cryo-preserved cell cultures (orange and brown). Positively (black) and negatively oriented genes are annotated along the bottom. C Pair-wise, bi-variate scatter plots of whole fragments per kb per million values (x- and y-axis) using 10 kb genomic bins between A549, ATAC-seq replicates. Sample names are annotated along the diagonal. Pair-wise Pearson’s correlation statistic is annotated within subplots