Fig. 1

Different structuralisations of polypeptide chain of the sequence of polar (blue stars) and hydrophobic residues (red circles) (top line) depending on othe form of external force field. A Water environment directs the folding toward the micelle-like structuralisation with hydrophobic core and polar surface. B Hydrophobic environment directs the folding toward exposure of hydrophobic residues on the surface with polar residues concentrated in central part (membrane protein case). C Mixture of polar/hydrophobic compounds present in environment produces the unfolded structural form of polypeptide chain. D Bi-layer environment with separated polar and hydrophobic compounds directs folding process toward the polar structure with two poles: polar one and hydrophobic one