Table 3 Rediscovery of LION LBD cancer biology discoveries using SKiM
A | Cutoff date | B | A–B p value | C | B–C p value |
|---|---|---|---|---|---|
NF-κB | 2015 | Bcl-2 | 5 × 10–76 | Adenoma | 1 × 10–34 |
NOTCH1 | 2015 | senescence | 6 × 10–12 | C/EBPβ | 1 × 10–14 |
IL-17 | 2014 | p38α | 2 × 10–8 | MKP-1 | 3 × 10–9 |
Nrf2 | 2010 | ROS | 0 | Pancreatic cancer | 5 × 10–8 |
CXCL12 | 2016 | senescence | 2 × 10–7 | Thyroid cancer | 0.17 |