Table 2 Significant disease–drug associations predicted by SKiM that were later tested in clinical trials
Disease (A) | Cutoff date | Drug (C) | First clinical trial PMID (years before) | First hypothesis PMID (years before) | Prediction score rank |
|---|---|---|---|---|---|
Raynaud’s | 1985 | Fluoxetine | 11561116 (16) | 8434812 (8) | 3 |
Migraine | 1987 | Butorphanol | 2020612 (4) | 2020612 (4) | 82 |
1978 | Valproate | 3146862 (10) | 3146862 (10) | 15 | |
Alzheimer’s | 1995 | Androgens | 11561185 (6) | 9192613 (2) | 38 |
1995 | Fluvoxamine | 9161652 (2) | 9161652 (2) | 75 | |
Schizophrenia | 1995 | Moclobemide | 10435775 (4) | 10435775 (4) | 44 |