Table 1 Rediscovery of five classic LBD findings by Swanson and Smalheiser, using SKiM
A term | Cutoff date | Phenotype or symptom (B) | A–B p-value | Swanson–Smalheiser discovery (C) | B–C p-value | B–C prediction score rank |
|---|---|---|---|---|---|---|
Raynaud’s | 1985 | Blood viscosity | 2 × 10–33 | Dietary fish oil | 5 × 10–10 | 462 |
Migraine | 1987 | Seizures | 6 × 10–24 | Magnesium | 7 × 10–36 | 822 |
Depression | 2 × 10–36 | 2 × 10–18 | ||||
Muscle spasms | 7 × 10–21 | 3 × 10–12 | ||||
Tension | 6 × 10–106 | 1 × 10–7 | ||||
Alzheimer’s | 1995 | Normal gait | 5 × 10–280 | Indomethacin | 5 × 10–229 | 253 |
Onset | 5 × 10–128 | 9 × 10–38 | ||||
Depression | 4 × 10–96 | 5 × 10–14 | ||||
Central nervous system disease | 3 × 10–50 | 4 × 10–6 | ||||
Alzheimer’s | 1995 | Normal gait | 5 × 10–280 | Estrogen | 0 | 95 |
Depression | 4 × 10–96 | 0 | ||||
Onset | 5 × 10–128 | 9 × 10–286 | ||||
Dermal atrophy | 3 × 10–127 | 8 × 10–43 | ||||
Central nervous system disease | 3 × 10–50 | 3 × 10–11 | ||||
Somatomedin C | 1989 | Normal gait | 2 × 10–192 | Arginine | 0 | 246 |
Paraganglioma | 2 × 10–33 | 0 | ||||
Glucose intolerance | 5 × 10–65 | 0 | ||||
Cognitive abnormality | 4 × 10–32 | 0 |