Fig. 6

Visualization of the new candidate putative compensatory mutation at coordinate 762199 from Table 12, as a subgraph of the pan-genome ccdBG of the 341-strain M. tuberculosis dataset (\(k=19\)). The first \(k-1\) overlapping characters have been omitted from each node for clarity. Parallel edges are collapsed into a single edge, shown with its multiplicity. Edge thickness also reflects multiplicity. The reference H37Rv strain follows the path of the dominating edges (i.e., node path 24491-71288-5413). Node 111083 is reported by our pipeline to be a candidate putative compensatory variation. The mutation of interest happens in codon 797, which is indicated in blue. Specifically, codon “GTC” is altered to codon “GTT”, which both translate to amino acid valine. Hence, this variation is a silent mutation