Table 2 HOT zones identified by the binding region and overlap methods compared with known promotorial and CpG-enriched areas in the 159 TF dataset
From: Identification of transcription factor high accumulation DNA zones
Method to search for HOT zones | HOT zones | CpG islands | Promotorial regions | Promotorial CpG islands | HOT zones in CpG islands | HOT zones in promoters | HOT zones in promotorial CpG islands | CpG islands in HOT zones | Promoters in HOT zones |
|---|---|---|---|---|---|---|---|---|---|
Binding region | 7442 | 28,691 | 49,052 | 23,153 | 5958 (80.1%) | 6064 (81.5%) | 5549 (74.6%) | 6335 (22.1%) | 10,652 (21.7%) |
Overlap (w = 0) | 3563 | 28,691 | 49,052 | 23,153 | 2673 (75.0%) | 2935 (84.4%) | 2497 (70.1%) | 2088 (7.3%) | 3796 (7.7%) |
Overlap (w = 1000) | 3253 | 28,691 | 49,052 | 23,153 | 2518 (77.4%) | 2818 (86.6%) | 2361 (72.6%) | 2523 (8.8%) | 4816 (9.8%) |