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Table 1 Average Pearson correlation and standard deviation for comparison approaches on 50 random train-test splits for the Maize dataset: multitrait linear mixed model with L1+trait-wise clustering penalty (mtLMM-clust), multitrait linear mixed model with L1 penalty (mtLMM-L1), multitrait linear model with L1+trait-wise clustering penalty (mtLM-clust),multitrait linear model with L1 penalty (mtLM-L1), single-trait RR-BLUP, applied to the rrBLUP R package (rrBLUP), multi-trait RR-BLUP, called Bayesian ridge regression (BRR) in the BGLR R package

From: Regularized multi-trait multi-locus linear mixed models for genome-wide association studies and genomic selection in crops

Trait

mtLMM-clust

mtLMM-L1

mtLM-clust

mtLM-L1

rrBLUP

BRR

\(\delta\)T3

\(0.42 \pm 0.11\)

\(0.39 \pm 0.08\)

\(0.32 \pm 0.17\)

\(0.28 \pm 0.14\)

\(\varvec{ 0.43 \pm 0.13}\)

\(0.23 \pm 0.06\)

\(\gamma\)T3

\(\varvec{0.56 \pm 0.13}\)

\(0.54 \pm 0.15\)

\(0.35 \pm 0.12\)

\(0.25 \pm 0.17\)

\(0.41 \pm 0.14\)

\(0.27 \pm 0.05\)

\(\alpha\)T3

\(0.46 \pm 0.15\)

\(0.44 \pm 0.25\)

\(0.48 \pm 0.23\)

\(0.44 \pm 0.14\)

\(\varvec{0.51 \pm 0.13}\)

\(0.38 \pm 0.05\)

\(\delta\)T

\(\varvec{0.48 \pm 0.17}\)

\(0.42 \pm 0.36\)

\(0.23 \pm 0.38\)

\(0.13 \pm 0.13\)

\(0.42 \pm 0.15\)

\(0.28 \pm 0.05\)

\(\gamma\)T

\(0.29 \pm 0.12\)

\(0.26 \pm 0.23\)

\(0.25 \pm 0.26\)

\(0.23 \pm 0.13\)

\(\varvec{0.34 \pm 0.17}\)

\(0.23 \pm 0.06\)

\(\alpha\)T

\(\varvec{0.68 \pm 0.14}\)

\(0.61 \pm 0.17\)

\(0.55 \pm 0.10\)

\(0.56 \pm 0.13\)

\(0.52 \pm 0.13\)

\(0.36 \pm 0.04\)

PC8

\(0.53 \pm 0.17\)

\(\varvec{0.54 \pm 0.27}\)

\(0.34 \pm 0.27\)

\(0.23 \pm 0.17\)

\(0.43 \pm 0.14\)

\(0.26 \pm 0.05\)

Total T3

\(\varvec{0.55 \pm 0.13}\)

\(0.52 \pm 0.19\)

\(0.26 \pm 0.17\)

\(0.25 \pm 0.15\)

\(0.42 \pm 0.14\)

\(0.32 \pm 0.05\)

Total T

\(\varvec{0.34 \pm 0.15}\)

\(0.34 \pm 0.24\)

\(0.28 \pm 0.29\)

\(0.34 \pm 0.14\)

\(0.30 \pm 0.17\)

\(0.20 \pm 0.06\)

Total T3 + T

\(\varvec{0.40 \pm 0.11}\)

\(0.36 \pm 0.12\)

\(0.37 \pm 0.14\)

\(0.27 \pm 0.17\)

\(0.34 \pm 0.15\)

\(0.23 \pm 0.05\)

\(\delta\)T/(\(\gamma\)T + \(\alpha\)T)

\(\varvec{0.54 \pm 0.13}\)

\(0.53 \pm 0.19\)

\(0.27 \pm 0.23\)

\(0.14 \pm 0.10\)

\(0.44 \pm 0.15\)

\(0.32 \pm 0.05\)

\(\delta\)T/\(\gamma\)T

\(\varvec{0.48 \pm 0.14}\)

\(0.48 \pm 0.18\)

\(0.43 \pm 0.23\)

\(0.14 \pm 0.11\)

\(0.33 \pm 0.17\)

\(0.26 \pm 0.05\)

\(\delta\)T/\(\alpha\) T

\(\varvec{0.66 \pm 0.14}\)

\(0.62 \pm 0.09\)

\(0.52 \pm 0.12\)

\(0.46 \pm 0.12\)

\(0.59 \pm 0.09\)

\(0.35 \pm 0.05\)

\(\gamma\)T/(\(\gamma\)T + \(\alpha\)T)

\(\varvec{0.58 \pm 0.13}\)

\(0.55 \pm 0.14\)

\(0.57 \pm 0.16\)

\(0.48 \pm 0.12\)

\(0.55 \pm 0.11\)

\(0.33 \pm 0.06\)

\(\delta\)T3/(\(\gamma\)T3 + \(\alpha\)T3)

\(0.31 \pm 0.10\)

\(0.33 \pm 0.14\)

\(0.27 \pm 0.22\)

\(0.34 \pm 0.14\)

\(\varvec{0.38 \pm 0.17}\)

\(0.26 \pm 0.06\)

\(\delta\)T3/\(\gamma\)T3

\(0.29 \pm 0.13\)

\(0.28 \pm 0.23\)

\(0.21 \pm 0.29\)

\(0.34 \pm 0.14\)

\(\varvec{0.30 \pm 0.16}\)

\(0.23 \pm 0.06\)

\(\delta\)T3/\(\alpha\)T3

\(0.38 \pm 0.09\)

\(0.38 \pm 0.13\)

\(0.25 \pm 0.14\)

\(0.24 \pm 0.14\)

\(\varvec{0.42 \pm 0.13}\)

\(0.26 \pm 0.05\)

\(\gamma\)T3/(\(\gamma\)T3 + \(\alpha\)T3)

\(\varvec{0.45 \pm 0.13}\)

\(0.44 \pm 0.17\)

\(0.34 \pm 0.15\)

\(0.21 \pm 0.11\)

\(0.38 \pm 0.12\)

\(0.16 \pm 0.06\)

\(\alpha\)T/\(\gamma\)T

\(0.52 \pm 0.12\)

\(0.49 \pm 0.18\)

\(0.52 \pm 0.19\)

\(0.54 \pm 0.11\)

\(\varvec{0.53 \pm 0.12}\)

\(0.35 \pm 0.05\)

\(\alpha\)T3/\(\gamma\)T3

\(0.41 \pm 0.12\)

\(\varvec{0.43 \pm 0.16}\)

\(0.32 \pm 0.12\)

\(0.29 \pm 0.13\)

\(0.39 \pm 0.12\)

\(0.14 \pm 0.06\)

All

\(\varvec{0.47\pm 0.13}\)

\(0.45\pm 0.18\)

\(0.36\pm 0.20\)

\(0.31\pm 0.13\)

\(0.42\pm 0.14\)

\(0.27 \pm 0.05\)

  1. Values in bold-faced font indicate the model with the highest Pearson correlation
  2. The CV1 cross validation procedure was used as described in the Materials and Methods, and performance was evaluated on unseen lines. The 20 traits, listed in the first column, considered are tocopherol (T) and tocotrienol (T3) traits measured in maize grain from [31]. \(\delta\)T3: delta-tocotrienol; \(\gamma\)T3: gamma-tocotrienol; \(\alpha\)T3: alpha-tocotrienol; \(\delta\)T: delta-tocopherol; \(\gamma\)T: gamma-tocopherol; \(\alpha\)T: alpha-tocopherol; PC8: Plastochromanol-8; Total T3: \(\delta\)T3 + \(\gamma\)T3 + αT3; Total T: \(\delta\)T + γT + αT; Total T3  +  T: Total T3 + Total T; The remaining traits are ratios of the tocopherol or tocotrienol compounds previously described