Table 5 The comparison between the performance of DrugRep-HeSiaGraph and DrugRep-KG based on four versions of DDKGs
Model | DDKG version | ACC (%) | AUC-ROC (%) | AUC-PR (%) | BS (%) | MCC (%) | F1-score (%) |
|---|---|---|---|---|---|---|---|
DrugRep-HeSiaGraph | DDKG-V1 | \(84.63 \pm 0.02\) | \(91.16 \pm 0.04\) | \(90.32 \pm 0.13\) | \(11.90 \pm 0.04\) | \(69.31 \pm 0.82\) | \(83.13 \pm 0.12\) |
DDKG-V2 | \(83.44 \pm 0.10\) | \(90.63 \pm 0.07\) | \(90.09 \pm 0.19\) | \(12.01 \pm 0.05\) | \(67.53 \pm 0.13\) | \(80.54 \pm 0.27\) | |
DDKG-V3 | \(84.51 \pm 0.04\) | \(90.97 \pm 0.03\) | \(90.27 \pm 0.41\) | \(12.00 \pm 0.04\) | \(69.12 \pm 0.14\) | \(82.84 \pm 0.08\) | |
DDKG-V4 | \(83.91 \pm 0.08\) | \(91.15 \pm 0.10\) | \(90.17 \pm 0.27\) | \(12.06 \pm 0.03\) | \(67.90 \pm 0.35\) | \(82.08 \pm 0.19\) | |
DrugRep-KG | DDKG-V1 | \(83.9\) 3 | \(91.00\) | \(90.30\) | \(11.97\) | \(67.90\) | \(82.83\) |
DDKG-V2 | \(83.92\) | \(90.57\) | \(89.94\) | \(12.18\) | \(67.50\) | \(83.04\) | |
DDKG-V3 | \(82.45\) | \(91.03\) | \(90.18\) | \(12.15\) | \(64.99\) | \(82.73\) | |
DDKG-V4 | \(82.45\) | \(90.94\) | \(89.97\) | \(12.24\) | \(64.92\) | \(81.89\) | |
DisDrugPred | – | – | 58.73 | 53.45 | 38.91 | – | – |
DRP-VEM | – | 52.33 | 55.37 | 55.12 | 29.76 | 32.43 | 52.35 |