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Table 4 Type I error from 2000 simulations with 15, 30, and 45 omics variables using five components with 1 continuous variable for clustering

From: TreeKernel: interpretable kernel machine tests for interactions between -omics and clinical predictors with applications to metabolomics and COPD phenotypes

 

Test

TreeKernel

Univariate simes

Principal component F-test

15 omics variables

4-partition

0.051

0.056

0.050

3-partition

0.051

0.041

0.053

2-Partition

0.057

0.050

0.047

30 omics variables

4-partition

0.047

0.048

0.053

3-partition

0.047

0.046

0.048

2-Partition

0.057

0.040

0.058

45 omics variables

4-partition

0.040

0.053

0.047

3-partition

0.040

0.054

0.052

2-Partition

0.049

0.052

0.052