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Table 3 Estimated power from 2000 simulations with 15, 30, and 45 omics variables using five components for clustering with 2 discrete grouping variables

From: TreeKernel: interpretable kernel machine tests for interactions between -omics and clinical predictors with applications to metabolomics and COPD phenotypes

 

Test

TreeKernel

Univariate simes

Principal component F-test

15 omics variables

4-Partition

 2 Active groups

Group 1

Group 2

Group 1

Group 2

Group 1

Group 2

 

0.656

0.348

0.003

0.017

0.716

0.410

 1 Active group

0.848

0.141

0.878

   

30 omics variables

4-Partition

 2 Active groups

Group 1

Group 2

Group 1

Group 2

Group 1

Group 2

 

0.693

0.481

0.004

0.006

0.530

0.398

 1 Active group

0.827

0.024

0.680

   

45 omics variables

4-Partition

 2 Active groups

Group 1

Group 2

Group 1

Group 2

Group 1

Group 2

 

0.729

0.608

0.005

0.007

0.426

0.374

 1 Active group

0.777

0.024

0.546

   
  1. ‘Group 1’ and ‘Group 2’ refer to the two partitions where the outcome was related to the simulated pathway
  2. Bold cells indicate highest power in the simulation setting
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BMC Bioinformatics

ISSN: 1471-2105

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