Table 3 DE analysis results using iDESC of the top 10 up-regulated DE genes, identified in the Kaminski macrophage dataset, in the three IPF macrophage datasets
From: iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects
Gene | Kaminski | Kropski | Misharin | |||
|---|---|---|---|---|---|---|
Fold change | P value | Fold change | P value | Fold change | P value | |
FN1 | 2.882 | 7.01×10−32 | 2.639 | 3.69×10−10 | NA | NA |
CCL18 | 2.528 | 3.95×10−22 | 2.594 | 3.68×10−4 | 1.725 | 5.79×10−4 |
SPP1 | 2.201 | 6.39×10−13 | 2.444 | 1.63×10−3 | NA | NA |
S100A10 | 1.827 | 2.75×10−17 | 2.418 | 3.27×10−4 | NA | NA |
VIM | 1.807 | 1.19×10−29 | NA | NA | 1.392 | 1.14×10−3 |
CSTB | 1.777 | 2.79×10−21 | 2.247 | 3.11×10−8 | 2.106 | 2.35×10−3 |
CD9 | 1.702 | 2.71×10−17 | 1.517 | 8.90×10−3 | 1.677 | 2.44×10−3 |
LGALS1 | 1.690 | 8.79×10−11 | 2.033 | 2.22×10−6 | 1.633 | 9.19×10−4 |
ACTB | 1.568 | 6.02×10−9 | NA | NA | 1.597 | 7.35×10−3 |
LGALS3 | 1.508 | 1.00×10−13 | 1.929 | 1.83×10−3 | 1.530 | 4.30×10−3 |