Fig. 1
From: iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects
Dependency of dropout rate on gene expression. Plots showing the gene-level proportion of zeros in relation to the average log-normalize UMI count across all cells in a the Kaminski and Misharin macrophage datasets and b the Kaminski and Kropski fibroblast datasets. The LOESS curves (red lines) described decreasing patterns of dropout rate on gene expression level. The subject-level LOESS curves in c the Kaminski and Misharin macrophage datasets and d the Kaminski and Kropski fibroblast datasets demonstrated heterogeneity of this dependency across different subjects