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Table 3 Summary of the running times for several database update intervals

From: Progressive search in tandem mass spectrometry

 

1 month

2 months

3 months

4 months

5 months

A (unit: second)

 1. Comet search

34,287.5

35,073.6

35,052.1

34,840.2

35,559.4

 2-a. Comet-P (without E-value)

635.9

1282.6

1439.5

1532.8

2045.3

 2-b. Comet-E (with E-value)

2075.7

2779.3

2834.0

2960.5

3476.1

  2.1. Database separation

3.0

3.0

3.0

3.2

3.1

  2.2. Deletion

344.3

410.0

459.0

498.8

598.3

   2.2.1. Extract spectra

15.6

15.8

15.0

16.3

15.7

   2.2.2. Comet-P/E search

158.7

184.9

199.5

216.2

251.7

   2.2.3. Update results

170.0

209.3

244.5

266.3

330.8

  2.3. Insertion

288.6

869.6

977.5

1030.8

1443.9

   2.3.1. Comet-P/E search

213.7

787.8

893.9

946.9

1354.8

   2.3.2. Update results

74.9

81.8

83.6

83.9

89.1

  2.4. E-value calculation

1439.8

1496.7

1394.5

1427.8

1430.8

B

The running time ratio

 Comet-P

1.85%

(× 53.92)

3.66%

(× 27.35)

4.11%

(× 24.35)

4.40%

(× 22.73)

5.75%

(× 17.39)

 Comet-E

6.05%

(× 16.52)

7.92%

(× 12.62)

8.09%

(× 12.37)

8.50%

(× 11.77)

9.78%

(× 10.23)

 Deletion

1.00%

1.17%

1.31%

1.43%

1.68%

 Insertion

0.84%

2.48%

2.79%

2.96%

4.06%

 E-value

calculation

4.20%

4.27%

3.98%

4.10%

4.02%

Database size ratio

 |Ddel |/|Dnew|*

0.02%

(8821 / 56,400,212)

0.11%

(64,323 / 57,348,066)

0.21%

(118,748 / 57,471,311)

0.26%

(149,505 / 57,516,232)

0.44%

(252,754 / 58,101,266)

 |Dins|/|Dnew|*

0.14%

(76,988 / 56,400,212)

1.88%

(1,080,344 / 57,348,066)

2.19%

(1,258,014 / 57,471,311)

2.32%

(1,333,692 / 57,516,232)

3.48%

(2,021,975 / 58,101,266)

Deleted PSMs ratio (|Sdel|/|S|)

0.02%

(226 / 1,121,149)

0.10%

(1121 / 1,121,149)

0.15%

(1717 / 1,121,149)

0.21%

(2410 / 1,121,149)

0.31%

(3426 / 1,121,149)

  1. (A) Running time Comparison between Comet, Comet-P, and Comet-E with several database update intervals. (B) Statistics of the running times. *The numerator and the denominator are the numbers of amino acids in target database only. If they are the numbers in both target and decoy databases, they are doubled and thus the ratio is still the same