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Table 1 Summary of the simulation scheme

From: Spatial rank-based multifactor dimensionality reduction to detect gene–gene interactions for multivariate phenotypes

 

Factor

Level

Value

Ref

Genotype

Number of SNPs

20

SNP1, …, SNP20

 

Number of causal SNPs

2

SNP1, SNP2

 

Minor allele frequency

2

0.2, 0.4

 

Heritability

7

0.01, 0.025, 0.05, 0.1, 0.2, 0.3, 0.4

 

Interaction model

5

M1, M2, M3, M4, M5

[7]

Phenotype

Number of phenotypes

2

Y1, Y2

 

Distributions

2

bivariate normal, bivariate gamma

[24, 44]

Correlation

3

0, 0.25, 0.5

 

Sample

Sample size

3

100, 200, 400

 

Analysis

Methods

 

MR-MDR (transformed, untransformed)

[24]

8

multi-CMDR

[23, 24]

 

multi-QMDR (FPC, WPC, WSPC)

[15]

 

QMDR (Y1, Y2)

 
  1. FPC first principal component, WPC use weighted Summation of principal component, WSPC use weighted Squared Summation of principal component