Fig. 1

Performance of the cell-type estimation when a marker is missing. Performance of the cell-type estimation when an amplicon is excluded as compared to the optimal model. Solid lines indicate the performance of the estimation when an amplicon is excluded for CD3⁺, CD14⁺, CD15⁺ and CD19⁺, respectively. Dashed lines indicate the value of the optimal model. The excluded amplicon is indicated on the x-axis. The y-axes show a the root mean square error (RMSE); b the Pearson correlation between the estimated cell-type proportions and the true values; c the mean estimated cell-type proportion for the sample with known proportions; and d the standard deviation of the estimated cell-type proportions