Table 1 Comparison between competing proteome allocation-based hypotheses and models for explaining the overflow metabolism
| Â | Molecular crowding | Constrained proteome allocation | Membrane occupancy | RBA and ME |
|---|---|---|---|---|
Physiological root cause | Finite cell volume | Un-specified | Finite membrane area | Limited translational efficiency and/or limited catalytic rate of enzymes |
Global or local regulation | Global | Global | Local | Global |
Types of limitation | Space limitation | Un-specified | Space limitation | Machinery limitation |
References | [4] |