Description | Gene markers | LUAD | LUSC | ||||||
---|---|---|---|---|---|---|---|---|---|
None | Purity | None | Purity | ||||||
Cor | P | Cor | P | Cor | P | Cor | P | ||
Monocyte | CD14 | 0.262 | *** | 0.2 | *** | 0.425 | *** | 0.323 | *** |
CSF1R | 0.503 | *** | 0.463 | *** | 0.553 | *** | 0.482 | *** | |
CD86 | 0.395 | *** | 0.344 | *** | 0.444 | *** | 0.349 | *** | |
TAM | CCL2 | 0.254 | *** | 0.19 | *** | 0.368 | *** | 0.296 | *** |
CD80 | 0.385 | *** | 0.331 | *** | 0.383 | *** | 0.294 | *** | |
CD68 | 0.383 | *** | 0.339 | *** | 0.382 | *** | 0.29 | *** | |
M1 | IRF5 | 0.323 | *** | 0.277 | *** | 0.068 | 0.126 | 0.049 | 0.281 |
NOS2 | 0.22 | *** | 0.194 | *** | 0.062 | 0.165 | 0.071 | 0.122 | |
M2 | CD163 | 0.45 | *** | 0.414 | *** | 0.458 | *** | 0.378 | *** |
ARG1 | 0.113 | * | 0.11 | 0.015 | − 0.069 | 0.125 | − 0.074 | 0.107 | |
MS4A4A | 0.352 | *** | 0.3 | *** | 0.345 | *** | 0.24 | *** | |
CD8+ T cell | CD8A | 0.248 | *** | 0.177 | *** | 0.262 | *** | 0.175 | ** |
CD8B | 0.118 | * | 0.051 | 0.257 | 0.188 | *** | 0.135 | * | |
B cell | CD19 | 0.121 | * | 0.02 | 0.653 | 0.277 | *** | 0.146 | * |
CD79A | 0.137 | * | 0.047 | 0.295 | 0.323 | *** | 0.198 | *** | |
Neutrophils | CEACAM8 | 0.259 | *** | 0.252 | *** | 0.072 | 0.106 | 0.048 | 0.293 |
MPO | 0.22 | *** | 0.183 | *** | 0.342 | *** | 0.29 | *** | |
CCR7 | 0.361 | *** | 0.295 | *** | 0.39 | *** | 0.291 | *** | |
CD11b(ITGAM) | 0.472 | *** | 0.435 | *** | 0.578 | *** | 0.517 | *** | |
Dendritic cell | HLA-DPB1 | 0.313 | *** | 0.249 | *** | 0.457 | *** | 0.371 | *** |
HLA-DQB1 | 0.253 | *** | 0.192 | *** | 0.328 | *** | 0.245 | *** | |
HLA-DRA | 0.281 | *** | 0.215 | *** | 0.387 | *** | 0.292 | *** | |
HLA-DPA1 | 0.353 | *** | 0.3 | *** | 0.454 | *** | 0.371 | *** | |
BDCA-1(CD1C) | 0.294 | *** | 0.243 | *** | 0.341 | *** | 0.227 | *** | |
BDCA-4(NRP1) | 0.386 | *** | 0.377 | *** | 0.523 | *** | 0.473 | *** | |
CD11C(ITGAX) | 0.383 | *** | 0.327 | *** | 0.513 | *** | 0.427 | *** | |
CD141(THBD) | 0.366 | *** | 0.344 | *** | 0.032 | 0.469 | − 0.006 | 0.89 | |
NK cell | KIR2DL1 | 0.046 | 0.296 | 0.023 | 0.612 | 0.143 | * | 0.091 | 0.047 |
KIR2DL3 | 0.104 | 0.019 | 0.06 | 0.187 | 0.158 | ** | 0.117 | 0.010 | |
KIR2DL4 | 0.062 | 0.163 | 0.015 | 0.737 | 0.113 | 0.011 | 0.051 | 0.265 | |
KIR3DL1 | 0.064 | 0.15 | 0.024 | 0.601 | 0.241 | *** | 0.187 | *** | |
KIR3DL2 | 0.139 | * | 0.087 | 0.053 | 0.141 | * | 0.069 | 0.134 | |
KIR3DL3 | 0.002 | 0.964 | − 0.019 | 0.67 | 0.029 | 0.52 | 0.002 | 0.962 | |
KIR2DS4 | 0.119 | * | 0.082 | 0.068 | 0.122 | * | 0.093 | 0.043 | |
CD7 | 0.168 | ** | 0.091 | 0.043 | 0.339 | *** | 0.237 | *** | |
XCL1 | 0.036 | 0.416 | 0.004 | 0.931 | − 0.015 | 0.742 | 0.017 | 0.705 | |
Th1 | T-bet (TBX21) | 0.322 | *** | 0.263 | *** | 0.363 | *** | 0.273 | *** |
STAT4 | 0.336 | *** | 0.274 | *** | 0.49 | *** | 0.415 | *** | |
STAT1 | 0.398 | *** | 0.364 | *** | 0.298 | *** | 0.251 | *** | |
IFN-γ (IFNG) | 0.129 | * | 0.06 | 0.181 | 0.121 | * | 0.057 | 0.216 | |
TNF-α (TNF) | 0.271 | *** | 0.229 | *** | 0.402 | *** | 0.345 | *** | |
Th2 | GATA3 | 0.435 | *** | 0.387 | *** | 0.551 | *** | 0.517 | *** |
STAT6 | 0.293 | *** | 0.318 | *** | 0.265 | *** | 0.284 | *** | |
STAT5A | 0.53 | *** | 0.495 | *** | 0.549 | *** | 0.491 | *** | |
IL13 | 0.079 | 0.072 | 0.032 | 0.479 | 0.152 | ** | 0.083 | 0.072 | |
Treg | FOXP3 | 0.354 | *** | 0.297 | *** | 0.481 | *** | 0.402 | *** |
STAT5B | 0.46 | *** | 0.45 | *** | 0.274 | *** | 0.288 | *** | |
TGFβ (TGFB1) | 0.487 | *** | 0.451 | *** | 0.312 | *** | 0.266 | *** | |
CCR8 | 0.422 | *** | 0.378 | *** | 0.442 | *** | 0.358 | *** | |
CD25(IL2RA) | 0.357 | *** | 0.305 | *** | 0.368 | *** | 0.273 | *** | |
T cell exhaustion | PD-1(PDCD1) | 0.225 | *** | 0.144 | * | 0.357 | *** | 0.267 | *** |
CTLA4 | 0.274 | *** | 0.197 | *** | 0.331 | *** | 0.221 | *** | |
LAG3 | 0.173 | *** | 0.104 | 0.021 | 0.257 | *** | 0.181 | *** | |
TIM-3 (HAVCR2) | 0.371 | *** | 0.314 | *** | 0.391 | *** | 0.292 | *** |