Fig. 4

Nullclines plot under the assumption of non-constant RseA concentration. When RseA concentration is subject to proteolitic degradation by ClpC1P2, the number of intersection points between the input–output relationships from Module 1 and from Module 2 shows that the closed-loop system is bistable. For the ease of readability, the logarithmic scale has been adopted for x- and y-axis. E stands for SigE