From: Estimation of total mediation effect for high-dimensional omics mediators
\(R^2_{Mediated}\) | SOS | ab | ab (Lasso) | prop | prop (Lasso) | ratio | ratio (Lasso) | |
---|---|---|---|---|---|---|---|---|
H1 | 0.0006 | 0.0013 | \(-0.0084\) | \(-0.0324\) | 0.0001 | 0.0069 | \(-0.0107\) | \(-0.0231\) |
(\(\hat{{\mathbf {M}}} = \mathbf{M }\)) | (0.0181) | (0.0370) | (0.2846) | (0.2744) | (0.0833) | (0.0795) | (0.1161) | (0.1117) |
H2 | 0.0146 | 0.0299 | 0.1602 | \(-0.0359\) | \(-0.0493\) | 0.0058 | 0.0075 | \(-0.0212\) |
(\(\hat{{\mathbf {M}}} = [\mathbf{M }, \mathbf{M }^{{(2)}}]\)) | (0.0184) | (0.0375) | (0.6463) | (0.2604) | (0.1960) | (0.0777) | (0.2886) | (0.1165) |
H3 | 0.0006 | 0.0053 | 0.0923 | 0.0547 | \(-0.0552\) | \(-0.0520\) | \(-0.0013\) | \(-0.0315\) |
(\(\hat{{\mathbf {M}}} = [\mathbf{M }, \mathbf{M }^{{(1)}}]\)) | (0.0071) | (0.0653) | (0.7443) | (0.7547) | (0.2520) | (0.2495) | (0.2983) | (0.3392) |
H4 | 0.0047 | 0.0095 | 0.1421 | \(-0.0347\) | \(-0.0447\) | 0.0025 | 0.0498 | \(-0.0196\) |
(\(\hat{{\mathbf {M}}} = [\mathbf{M }, noise]\)) | (0.0198) | (0.0403) | (0.2613) | (0.2519) | (0.0785) | (0.0689) | (0.0982) | (0.1055) |
H5 | \(-0.0000\) | \(-0.0000\) | \(-0.0867\) | \(-0.3449\) | \(-0.0173\) | \(-0.0293\) | \(-0.0532\) | \(-0.2327\) |
(\(\hat{{\mathbf {M}}} = \mathbf{M }\)) | (0.0095) | (0.0109) | (0.0956) | (0.1618) | (0.0158) | (0.0184) | (0.0482) | (0.0295) |