Fig. 2
From: ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach
ChIP-BIT2 pipeline. ChIP-BIT2 respectively extracted read location information from sample and input ChIIP-seq SAM format profiles. Depending on the running mode, it can detect peaks from the whole genome or from annotated regulatory regions like promoters or enhancers. To enable peak detection of different sizes, ChIP-BIT2 partitioned genomic segments into smaller windows and calculated read intensity in each window for distribution parameter learning and binding occurrence probability estimation. Windows with the posterior probability over 0.9 were output in BED format as final peaks