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Table 1 Comparison on progressive permutation results produced by multiple simulated data sets with different simulation parameters, including correlation \(\rho\), number of significant variables (nsv), group mean difference (\(m_1-m_2\)), and dispersion \(\kappa\)

From: ProgPerm: Progressive permutation for a dynamic representation of the robustness of microbiome discoveries

\(\rho\)

nsv

\(m_1-m_2\)

\(\kappa\)

AOI

AUMC

\({\mathrm {slope}}_0\)

\({\mathrm {slope}}_1\)

Fragility

\({\mathrm {select}}_0\)

\({\mathrm {select}}_1\)

0.5

30

9

24

0.30

0.23

0

− 0.54

6.64

30

30

9

1

0.30

0.20

0

− 0.54

5.74

30

30

4

24

0.30

0.18

0

− 0.52

5.96

30

30

4

1

− 0.05

− 0.05

0.45

0

1.44

5

3

0

24

0.00

− 0.02

0

0.1

0.44

0

0

0

1

0.00

− 0.02

0

0.1

0.46

0

0

90

9

24

1.00

0.67

0

− 2

11.02

100

100

9

1

1.00

0.58

0

− 1.98

10.14

100

100

4

24

0.89

0.44

− 0.6

− 1.74

8.84

89

84

4

1

− 0.08

− 0.08

1.5

− 0.08

2.06

8

3

0

24

0.00

− 0.02

0

0.1

0.34

0

0

0

1

0.00

− 0.02

0

0.1

0.5

0

0

0.8

30

9

24

0.30

0.23

0

− 0.54

6.58

30

30

9

1

0.30

0.20

0

− 0.54

5.8

30

30

4

24

0.30

0.18

0

− 0.52

5.14

30

30

4

1

0.04

0.04

− 0.45

0.02

1.2

4

0

0

24

0.00

− 0.02

0

0.1

0.66

0

0

0

1

0.00

− 0.02

0

0.1

0.3

0

0

90

9

24

1.00

0.67

0

− 2

11.12

100

100

9

1

1.00

0.58

0

− 1.98

10.1

100

100

4

24

0.97

0.45

− 2.1

− 1.9

8.82

97

87

4

1

− 0.07

− 0.08

2.25

− 0.04

2.06

7

0

0

24

0.00

− 0.02

0

0.08

0.54

0

0

0

1

0.00

− 0.02

0

0.1

0.2

0

0

  1. AOI is short for area of interest. AUMC is short for area under the mixing curve. “\({\mathrm {slope}}_0\)” denotes the slope of the first point in the U-Curve of number of significant features (the slope of the line connecting the first two points). “\({\mathrm {slope}}_1\)” denotes the average value of the slope of the first 15 points (\(K_f=15\)) in the U-Curve of number of significant features (the slope of the line connecting the point with its next neighbor). “fragility” denotes the average value of the fragility index of the first 50 microbiome features. “\({\mathrm {select}}_0\)” denotes the number of p-values that are less than 0.05 given by the testing results on the observed data. “\({\mathrm {select}}_1\)” denotes the number of significant features identified by the proposed method