Table 5 Comparison between QuaDMutNetEx, HotNet2, DriverNet, and Dendrix
From: QuaDMutNetEx: a method for detecting cancer driver genes with low mutation frequency
Method | Genes in solution | Coverage | Excess coverage | Dendrix score | Connected components |
|---|---|---|---|---|---|
TN: Triple negative breast cancer | Â | Â | Â | Â | Â |
HotNet2 | 128 | 0.6809 | 0.7969 | -118 | 9 |
DriverNet | 21 | 0.6383 | 0.4667 | 23 | 14 |
Dendrix | 22 | 0.6170 | 0.1034 | 51 | 8 |
QuaDMutNetEx | 13 | 0.6854 | 0.0983 | 55 | 3 |
GBM: Glioblastoma multiforme | Â | Â | Â | Â | Â |
HotNet2 | 37 | 0.7833 | 0.4149 | 10 | 11 |
DriverNet | 17 | 0.9333 | 0.8661 | -140 | 9 |
Dendrix | 22 | 0.7166 | 0.023256 | 84 | 4 |
QuaDMutNetEx | 6 | 0.8151 | 0.1855 | 79 | 1 |
HGS: high-grade serous ovarian cancer | Â | Â | Â | Â | Â |
HotNet2 | 58 | 0.8449 | 0.4307 | 83 | 4 |
DriverNet | 72 | 0.9335 | 0.6373 | -35 | 51 |
Dendrix | 3 | 0.8037 | 0.0 | 254 | 3 |
QuaDMutNetEx | 25 | 0.6170 | 0.1086 | 236 | 1 |
METABRIC: breast cancer | Â | Â | Â | Â | Â |
HotNet2 | 224 | 0.4424 | 0.7394 | -1694 | 18 |
DriverNet | 90 | 0.4683 | 0.7785 | -1130 | 33 |
Dendrix | 18 | 0.3836 | 0.1236 | 233 | 16 |
QuaDMutNetEx | 25 | 0.3982 | 0.1753 | 216 | 4 |