Fig. 5
From: Variant effect predictions capture some aspects of deep mutational scanning experiments
Concept of analysis. Experimental scores of variant effects (missense mutations, or single amino acid variants, labelled SAVs) from Deep Mutational Scanning (DMS) experiments were compared to in silico prediction methods. Envision was the only method developed on DMS data; it provides continuous scores mirroring the DMS data. SIFT, PolyPhen-2 can be evaluated as binary classification methods. SNAP2 is a classification method but provides continuous scores that can also be used. Naïve Conservation is provided as a baseline for both cases