Method | Advantages | Disadvantages |
---|---|---|
FBA | Efficient to solve for steady-state fluxes; many metabolic engineering tools built around FBA | Cannot track metabolite dynamics |
ODE-based models | Able to track metabolite dynamics; accurately model reaction kinetics | Abundant kinetic parameters; difficult to scale up to large systems |
DFBA (DOA) | Able to track metabolite dynamics; does not require complex kinetic equations for each flux | Contains non-linear constraints that can make the optimization problem difficult to solve |
DFBA (SOA) | Able to track metabolite dynamics; does not require non-linear constraints | Cannot incorporate kinetic or regulatory information |