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Table 1 Advantages and disadvantages of several constraint-based and ODE-based models

From: LK-DFBA: a linear programming-based modeling strategy for capturing dynamics and metabolite-dependent regulation in metabolism

Method

Advantages

Disadvantages

FBA

Efficient to solve for steady-state fluxes; many metabolic engineering tools built around FBA

Cannot track metabolite dynamics

ODE-based models

Able to track metabolite dynamics; accurately model reaction kinetics

Abundant kinetic parameters; difficult to scale up to large systems

DFBA (DOA)

Able to track metabolite dynamics; does not require complex kinetic equations for each flux

Contains non-linear constraints that can make the optimization problem difficult to solve

DFBA (SOA)

Able to track metabolite dynamics; does not require non-linear constraints

Cannot incorporate kinetic or regulatory information