Skip to main content
Fig. 2 | BMC Bioinformatics

Fig. 2

From: LK-DFBA: a linear programming-based modeling strategy for capturing dynamics and metabolite-dependent regulation in metabolism

Fig. 2

Workflow for building metabolic models. Dynamic Flux Estimation is applied to the system stoichiometry and available metabolomics data to infer flux data. The system stoichiometry, metabolomics data, inferred flux data, and system regulatory information are then used to estimate parameters in each modeling framework (blue arrow), using linear or non-linear regression (green arrows). A secondary optimization step can be applied after LK-DFBA (LR) to further improve modeling accuracy (red arrows)

Back to article page