Fig. 6

ERK-MEK complex. The distributions of SIP for the ERK + MEK complex WTDs are bimodal. The modes are at T equal to 4 s and 15 s. When T_{MEKact + ERKd → ERKact} = 8 s, the mode at T = 15 s shifts to 17 s. The non-normalized histograms on the left column show that the total number of events is at the minimum when T_{MEKact + ERKd → ERKact} has the maximum value simulated equal to 1320s. The number of critical events increases when T_{MEKact + ERKd → ERKact} decreases and reaches a critical value after which the dissociation time is directly proportional to the number of events