Fig. 4

Average values of a the relative ASA at each position of the peptide substrates modelled for structures 2age (red and orange) and 1tps (blue and cyan) with MEROPS id S01.151 (trypsin I) from two independent random peptide libraries, and b the interaction energy calculated using the Rosetta scoring function. Similarly, the mean values of c the relative ASA at each position of the peptide substrates modelled for structures 4dt7 (green and lime) and 1ycp (purple and pink) with MEROPS id S01.217 (thrombin) from two independent random peptide libraries, and d the interaction energy calculated using the Rosetta scoring function. The second library is named as 2L in the figure labels