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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Quantitative Structure–Mutation–Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction

Fig. 3

PPI network constructed by the interaction terms for predicting PKI response in NSCLC cell lines. Green node: protein kinase; dark green node: dark/understudied protein kinase [77]; yellow node: other protein; the node with a thick border: known PKI target; red edge: PPI with a positive impact on \(\hbox {IC}_{50}\); light red edge: PPI with a weak positive impact on \(\hbox {IC}_{50}\); blue edge: PPI with a negative impact on \(\hbox {IC}_{50}\); light blue edge: PPI with a weak negative impact on \(\hbox {IC}_{50}\); gray edge: PPI not in the prediction model

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BMC Bioinformatics

ISSN: 1471-2105

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