Table 4 Predictors of LGG CNV pathway-level (Hallmark) model and fitting results of Cox models
| Â | Multivariable Cox model | Univariable Cox model | ||||
|---|---|---|---|---|---|---|
Hazard ratios | se(coef) | p value | Hazard Ratios | se(coef) | p value | |
HYPOXIA | 2.59E−03 | 1.73 | 5.79E−04 | 0.04 | 1.15 | 5.24E−03 |
MYC_TARGETS_V1 | 507.05 | 2.16 | 3.85E−03 | 858.29 | 1.27 | 9.38E−08 |
CHOLESTEROL_HOMEOSTASIS | 13.96 | 1.08 | 1.49E−02 | 3.58 | 0.73 | 7.94E−02 |
PI3K_AKT_MTOR_SIGNALING | 25.10 | 1.37 | 1.86E−02 | 2043.83 | 0.97 | 4.75E−15 |
OXIDATIVE_PHOSPHORYLATION | 0.02 | 1.77 | 2.66E−02 | 0.03 | 1.34 | 7.16E−03 |
TGF_BETA_SIGNALING | 6.40 | 0.96 | 5.33E−02 | 42.35 | 0.61 | 7.89E−10 |
EPITHELIAL_MESENCHYMAL_TRANSITION | 11.00 | 1.79 | 1.79E−01 | 29.69 | 0.92 | 2.15E−04 |
IL2_STAT5_SIGNALING | 5.36 | 1.52 | 2.69E−01 | 3.74 | 1.21 | 2.73E−01 |
KRAS_SIGNALING_UP | 4.08 | 1.55 | 3.65E−01 | 151.12 | 0.86 | 5.18E−09 |
DNA_REPAIR | 3.07 | 1.36 | 4.10E−01 | 15.60 | 1.08 | 1.12E−02 |
MYC_TARGETS_V2 | 0.42 | 1.19 | 4.70E−01 | 0.38 | 0.77 | 2.14E−01 |
ESTROGEN_RESPONSE_LATE | 0.34 | 1.81 | 5.55E−01 | 0.01 | 1.18 | 1.35E−04 |
HEME_METABOLISM | 0.39 | 1.80 | 6.01E−01 | 0.01 | 1.47 | 2.40E−03 |
HEDGEHOG_SIGNALING | 0.75 | 0.70 | 6.82E−01 | 0.08 | 0.54 | 2.96E−06 |
ESTROGEN_RESPONSE_EARLY | 1.31 | 1.96 | 8.90E−01 | 1.94E−03 | 0.90 | 3.78E−12 |
NOTCH_SIGNALING | 1.04 | 0.75 | 9.54E−01 | 9.07 | 0.58 | 1.34E−04 |