Fig. 3
From: Moving forward through the in silico modeling of tuberculosis: a further step with UISS-TB
Outcome of digital patients treated with INH and RUTI vaccine. Green line shows the average trend of cell populations, while the orange shaded area represents the standard deviation. One month after the end of antibiotic treatment, RUTI vaccine was administered accordingly to the clinical trial design. a Depicts the dynamics of AM before and after the administration of INH and after the administration of RUTI. The combination of INH with RUTI allows a better recovery of infected AM population when compared to the one without RUTI injection. Substantial increase in levels of TC, Th1, Th17 and IFNG is observed (b–e). For all the biological scenarios, simulation time has been set to 365 days (1 years) and digital patient have been challenged with MTB at day 15