Table 1 Top genes after P-value combination
From: NIMBus: a negative binomial regression based Integrative Method for mutation Burden Analysis
Rank | Gene | P value | Adjusted P value | PubMed ID |
|---|---|---|---|---|
1 | TP53 | 4.33E−139 | 4.3311E−139 | 17401424 |
2 | DDX3X | 7.30E−18 | 3.64888E−18 | 22820256 |
3 | KRAS | 7.68E−06 | 2.56097E−06 | 19847166 |
4 | MUC4 | 1.79E−05 | 4.46636E−06 | 19935676 |
5 | CDH1 | 1.53E−04 | 3.06519E−05 | 10973239 |
6 | ARID1A | 1.42E−03 | 0.000236255 | 22037554 |
7 | SMARCA4 | 2.64E−03 | 0.000377726 | 18386774 |
8 | FGFR1 | 5.94E−03 | 0.000742868 | 23817572 |
9 | OTOP1 | 3.33E−02 | 0.003694811 | – |
10 | STK11 | 4.69E−02 | 0.004691876 | – |
11 | SPOP | 4.94E−02 | 0.004493795 | – |
12 | PTEN | 5.77E−02 | 0.004812088 | – |
13 | SMO | 1.65E−01 | 0.012684045 | – |
14 | TAS2R31 | 4.76E−01 | 0.033983962 | – |
15 | TBC1D29 | 5.14E−01 | 0.034276895 | – |