Table 1 Cox coefficients for the subC-LP or subC-CMS models trained on the AFLAME data. Values of the coefficients are indicated along with 95% confidence intervals and P-values

Component

beta [CI 95%]

Pbeta

gamma [CI 95%]

Pgamma

 beta0

−0.79 [−1.12, − 0.45]

4.20E-06

 C1

−1.77 [−6.79, 3.24]

4.90E-01

6.48 [0.73, 12.22]

2.70E-02

 C2

−1.21 [−3.83, 1.41]

3.70E-01

2.56 [−0.43, 5.54]

9.30E-02

 C3

3.49 [−0.44, 7.42]

8.20E-02

−5.94 [−10.35, − 1.53]

8.30E-03

 C4

−0.19 [−4.75, 4.36]

9.30E-01

2.79 [−2.55, 8.13]

3.10E-01

 C5

3.11 [−2.57, 8.78]

2.80E-01

−8.89 [−15.63, − 2.15]

9.70E-03

 C6

0.75 [−2.52, 4.02]

6.50E-01

−3.41 [−7.25, 0.43]

8.20E-02

Component

beta [CI 95%]

Pbeta

gamma [CI 95%]

Pgamma

 beta0

−0.75 [−1.08, − 0.42]

7.90E-06

 CMS1

5.81 [−12.96, 1.35]

1.10E-01

17.18 [6.91, 27.46]

1.00E-03

 CMS2

6.29 [−14.94, 2.36]

1.50E-01

19.15 [6.52, 31.78]

3.00E-03

 CMS3

−3.07 [−9.42, 3.27]

3.40E-01

12.02 [2.86, 21.18]

1.00E-02

CMS4

5.38 [−13.52, 2.76]

2.00E-01

16.79 [4.75, 28.83]

6.30E-03