Fig. 3

The framework of the proposed method. In the first step, the desired data are obtained from DrugR+ database. Next, drug-disease (D-DI), drug-target (D-T), and drug-drug-adverse reaction (D-D AR) matrices are formed. Drugs which can affect the HT inducing targets, are acquired based on the If-then rules. In the second step, the proposed optimization algorithm (Trader) is used to select a combination of drugs for the repurposing of medications for HT