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Fig. 4 | BMC Bioinformatics

Fig. 4

From: PS4DR: a multimodal workflow for identification and prioritization of drugs based on pathway signatures

Fig. 4

Distributions of the p-values resulting from SPIA true and simulated pathways represented as violin plots for a) KEGG, b) Reactome, and c) Biocarta pathway databases. Mann-Whitney U test confirmed that the distributions are significantly different for all three pathway databases (KEGG: p-value = 8.26e-102, Reactome: p-value = 3.05e− 114, Biocarta: p-value = 8.01e− 09). These results demonstrate that while true pathways yield meaningful results (i.e., lower p-values), simulated pathways are rarely significantly enriched

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