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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Simulating ComBat: how batch correction can lead to the systematic introduction of false positive results in DNA methylation microarray studies

Fig. 2

“mod” refers to a model matrix for the outcome of interest. a Boxplots of p-value distributions without added batch effects and under various conditions. Dotted line indicates expected mean p-value of 0.5. b Boxplots of p-value distributions with simulated batch effects and under various conditions. c Boxplots of FDR false significant sites without batch. d Boxplots of FDR false significant sites without batch. Boxplots for “without ComBat” are indicating the false positive sites due to uncorrected batch effects for the respective sample distributions

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BMC Bioinformatics

ISSN: 1471-2105

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