Fig. 1
From: RNA 3D structure prediction guided by independent folding of homologous sequences
RNA families tend to fold into the same 3D shape. Structures of the riboswitch c-di-AMP solved independently by three groups: for two different sequences obtained from Thermoanaerobacter pseudethanolicus (PDB ID: 4QK8) and Thermovirga lienii (PDB ID: 4QK9) [18] for a sequence from Thermoanaerobacter tengcongensis (PDB ID: 4QLM) [19] and for a sequence from Bacillus subtilis (PDB ID: 4 W90) (the molecule in blue is a protein used to facilitate crystallization) [20]. There is some variation between structures in the peripheral parts, but the overall structure of the core is conserved