Table 4 Comparison of PD versus non-PD individuals. Significant results are shown in bold type. For each gene the most significant result only of all SNV association tests is shown and for each these the rs id is provided. Additionally, the number of SNV association test conducted within each gene is indicated in brackets. No correction is made for testing of six genes nor for testing multiple SNVs within any given gene
Test PD vs non-affected samples | LRRK2 | PARK7 | PINK1 | PRKN | SNCA | VPS35 |
|---|---|---|---|---|---|---|
GenePy | 0.178 | 0.445 | 0.013 | 0.983 | 0.828 | 0.206 |
SKAT-O | 1 | 0.557 | 0.157 | 0.427 | 0.712 | 0.741 |
Top 5% comparison | 0.002 | 0.107 | 0.010 | 0.021 | 0.347 | 0.036 |
Most significant SNV (# tested) | 0.034 rs10878245 (88) | 0.081 rs71653621 (6) | 0.042 rs148871409 (21) | 0.051 rs1801582 (27) | 0.433 rs548523899 (7) | 0.433 rs168745 (17) |