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Fig. 5 | BMC Bioinformatics

Fig. 5

From: Quantification of experimentally induced nucleotide conversions in high-throughput sequencing datasets

Fig. 5

Quantification of nucleotide-conversions: a Sensitivity and specificity of SLAM-DUNK on simulated labeled reads vs recovered T > C containing reads for read lengths of 50, 100 and 150 bp and nucleotide-conversion rates of 2.4 and 7%. b Heatmap of the probability of detecting at least one read originating from a labeled transcript from a given fraction of labeled transcripts and coverage for a conversion rate of 2.4% and a read length of 50 bp. White color code marks the 0.95 probability boundary. c Distribution of relative errors of read-based and SLAM-DUNK’s T-content normalized based fraction of labeled transcript estimates for 18 genes with various T-content for 1000 simulated replicates each. d Distribution of relative errors of SLAM-DUNK’s T-content normalized fraction of labeled transcript estimates for 1000 genes with T > C conversion rates of 2.4 and 7% and sequencing depth from 25 to 200x

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BMC Bioinformatics

ISSN: 1471-2105

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