Table 1 Biological annotations of unique DMRs predicted by HOME, DSS and Metiene on the PV and EX methylome data. The top 20 terms were counted for neural system function related terms using the mouse phenotype annotation and MGI gene expression annotation. No. of Cs refers to the minimum number of cytosines required in a DMR and delta refers to the absolute change in methylation level
DMR finders | Best results were obtained for below threshold | No. of DMRs after thresholding | Phenotype (%) (terms counted out of 20) | Expression (%) (terms counted out of 20) |
|---|---|---|---|---|
HOME | No. of Cs > 5 and delta > 0.2 | 4721 | 85 | 70 |
DSS | No. of Cs > 5 and delta > 0.25 | 3066 | 60 | 35 |
Metilene | delta > 0.15 | 2495 | 10 | 15 |