Fig. 5

Snapshot of the Web Application and selected synergies. a Selected examples of synergies across some of the drugs: Absolute synergy (size of the dot) and specificity score (color code) are displayed. The top promiscuous drugs have a diverse profile of synergistic pairs and synergy pattern are different across different a selection of drugs synergies is. b The synergy score for all the drug pairs are displayed in a square heatmap. The lower triangle displays the absolute number of cell lines that displayed synergy for the drug pair, in a white to red color scale; the upper triangle displays the specificity score. When a drug pair is clicked, the corresponding viabilities for all cell lines is displayed in a dot plot. c Dot plot with the details on the synergy score. At the top the names of the drugs are shown, together with the absolute synergy score and the specificity score; then the detailed standard concentration results, and below the low concentration results, per cell line. The singlet viabilities for each drug estimated from the linear model are displayed in blue and green with standard error as a bar. The black dots show theoretical viability under assumption of independence of drug effect (no synergy). The red dots show the observed viability, with error bars as the standard deviation of the un-drugged wells. The error bars of the estimated singlet and the estimated combination under the independence assumption are the standard errors derived from the linear model (see methods). Hence, the distance between the black and red dots show the magnitude of the synergy (or antagonism). Significant synergies (p adjusted < 0.05) are shown with a black tick, and significant antagonism are shown with a pink tick