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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Genome-wide tracts of homozygosity and exome analyses reveal repetitive elements with Barrets esophagus/esophageal adenocarcinoma risk

Fig. 3

Display of pathways related to significant genes in cTOH regions. a Enriched pathways identified from EAC specific genes. Analysis of the key prioritized genes revealed the top ten enriched pathways. The intensity of the blue color bars reflects the importance of the pathway in BE/EAC. The top two pathways are the NOTCH signaling pathway and G protein-coupled signaling pathway. Other important pathways include the ER-to-Golgi and WNT pathways. b Enriched networks identified from EAC specific genes. Analysis of the key genes revealed the top ten functionally enriched process networks. The intensity of the blue color bars reflects the importance of the network processes in BE/EAC. The top nine network processes are likely important processes in BE/EAC. Transcriptional regulation and cholecystokinin signaling are the two top network processes for BE/EAC. NOTCH signaling, ER, and inflammation protein C signaling processes seem to be important in BE/EAC

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BMC Bioinformatics

ISSN: 1471-2105

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