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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Real world scenarios in rare variant association analysis: the impact of imbalance and sample size on the power in silico

Fig. 3

Power comparison of three models with differing contributions from protective and risk rare genetic variation. The results are shown for variants contributing low, moderate, or high impact on outcome risk or protection. Methods describe the range of odds ratios corresponding to the different categories. (a) Total sample size of 4000 for balanced cases and controls with MAF UB 0.05. (b) Total sample size of 4000 for balanced cases and controls with MAF UB 0.01. (c) 200 cases and 10,000 controls with MAF UB 0.05. (d) 200 cases and 10,000 controls with MAF UB 0.01

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BMC Bioinformatics

ISSN: 1471-2105

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