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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Real world scenarios in rare variant association analysis: the impact of imbalance and sample size on the power in silico

Fig. 2

Power simulation results with cutoff for evaluated variation of MAF 0.01. Fig. (a) shows the results when cases and controls are equal in number. Fig. (b) shows the impact of unbalanced cases and controls on power ranked by the case/control ratio. The percent case to control ratio is listed below the x-axis. Figs. (c and d) show the results for power with unbalanced cases and controls ordered by case number with 10,000 controls (c) and 30,000 controls (d)

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BMC Bioinformatics

ISSN: 1471-2105

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