Fig. 2
From: High-throughput cancer hypothesis testing with an integrated PhysiCell-EMEWS workflow
Hypothesis testing as an optimization problem. If scientific users can (1) formulate a range of hypotheses, (2) supply an efficient 3-D mechanistic simulator (BioFVM+PhysiCell), (3) provide validation behaviors and/or data, and (4) supply an error metric, then the combined PhysiCell-EMEWS system can automatically explore the space of hypotheses, initiate simulations on HPC/HTC resources, collect data to evaluate the error metric, and then make further decisions on which hypotheses and parameter values to explore next. The framework iteratively sharpens hypotheses that bring new biological and clinical insights