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Fig. 1 | BMC Bioinformatics

Fig. 1

From: High-throughput binding affinity calculations at extreme scales

Fig. 1

EGFR Structure. Cartoon representation of the EGFR kinase bound to the inhibitor AEE788 shown in chemical representation (based on PDB:2J6M). Two residues implicated in modulating drug efficacy are highlights; in pink T790 and in orange L858. Mutations to either of these residues significantly alter the sensitivity to TKIs

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