PASNet: pathway-associated sparse deep neural network for prognosis prediction from high-throughput data

BMC Bioinformatics

Table 3 Top-10 ranked pathways for survival prediction in GBM by PASNet

Pathway name	Pathway size	Reference	Top-5 ranked genes^a
Signaling by GPCR	920	[33]	SHH, PTGFR, GNG5, CHRM5, LHB
GPCR downstream signaling	805	[50]	PTGFR, OR7C2, GNG5, OR10H3, MLNR
Innate immune system	933	[35]	CD79B, INPPL1, SRC, NUP85, DNM2
Adaptive immune system	539	[51]	CD79B, ASB6, PTEN, NCF4, FBXO2
Metabolism of carbohydrates	247	-	HS3ST3B1, NUP85, PFKFB3, LUM, SLC2A4
Transmembrane transport of small molecules	413	[52]	SLC9A7, ABCA7, GNG5, AQP8, HK3
Developmental biology	396	-	NRP2, FES, WNT10B, MYOD1, SLC2A4
Metabolism of proteins	518	-	EIF3G, CCT2, TIMM22, RPL3L, GMPPA
Class A/1 (rhodopsin-like receptors)	305	[53]	PTGFR, OPRD1, CHRM5, NPFF, NTSR2
Axon guidance	251	[54]	NRP2, NRTN, AGRN, FES, RPS6KA4

ISSN: 1471-2105