Fig. 14
From: iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data
Additional effect of p53 in IR response. a Expression patterns of selected DEGs. b Upregulated genes are enriched with genes related to p53 mediated response to DNA damage, especially apoptosis, and negative regulation of cell cycle. These genes are only induced by IR in cells with wildtype p53. One the other hand, p53 caused the relative downregulation of genes related to ribosome biogenesis, tRNA and rRNA processing, DNA replication, and protein folding. These genes are only upregulated by IR in Trp53−/−