Table 4 Significant disease associated genes in the TGF– β family
From: Multi–omic analysis of signalling factors in inflammatory comorbidities
Disease | Up–regulated DEG | Down–regulated DEG | Up–regulated DMG | Down–regulated DMG |
|---|---|---|---|---|
Allergy | GDF11, LEFTY2, TGFB3 | — | — | GDF3, GDF15 |
Asthma | GDF2, GDF15, MSTN, INHBA, INHBB, INHBC | BMP4 | GDF2, GDF9, BMP15, MSTN, PSPN | — |
CFS | — | — | — | — |
Colitis | TGFB1, TGFB3, BMP15, INHBC, GDF9 | — | — | GDF15 |
Colon Cancer | — | — | PSPN | — |
Crohn | TGFB1, TGFB3, BMP15, INHBC | — | — | GDF15 |
RA | GDF11, GDF15, INHBA, BMP6 | GDF10, TGFB2, GDF3, ARTN, BMP4, GDF7, BMP5, INHBC, INHA | LEFTY2, TGFB3 | GDF1 |
SLE | BMP15, GDF9 | — | — | GDF3, GDF15 |
T2D | GDF15, INHBA | MSTN | PSPN | ARTN, INHBE |